Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions

Karcioglu O., Arnold J., Topacoglu H., ÖZÜÇELİK D. N., Kiran S., Sonmez N.

International Journal of Clinical Practice, vol.60, no.12, pp.1638-1646, 2006 (SCI-Expanded, Scopus) identifier identifier

  • Nəşrin Növü: Article / Review
  • Cild: 60 Say: 12
  • Nəşr tarixi: 2006
  • Doi nömrəsi: 10.1111/j.1742-1241.2006.00685.x
  • jurnalın adı: International Journal of Clinical Practice
  • Jurnalın baxıldığı indekslər: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Səhifə sayı: pp.1638-1646
  • Açar sözlər: Endotracheal intubation, Neuromuscular blockade, Rapid sequence Intubation, Rocuronium, Succinylcholine
  • Açıq Arxiv Kolleksiyası: Icmal
  • Adres: Yox

Qısa məlumat

This meta-analysis was undertaken to compare the effects of succinylcholine (SCH) and rocuronium (RCR) on endotracheal intubation (ETI) conditions. Eligible randomised controlled trials (RCTs) were identified via medline and a manual search of references. The frequencies of excellent and unacceptable ETI conditions in subjects receiving SCH 1.0-1.5mg/kg and RCR 0.6-1.2mg/kg were determined using standard statistical methods. Inclusion criteria were met by 16 RCTs, representing 1362 subjects. SCH was associated with a 17.7% increase (95% CI = 13-22) in the frequency of excellent ETI conditions and a 5.1% decrease (95% CI = 7.3 to -2.9) in the frequency of unacceptable ETI conditions, when compared with RCR. In the subgroup undergoing true rapid sequence intubation, SCH was associated with a 19.1% increase (95% CI = 13.7-24.5) in the frequency of excellent ETI conditions. SCH appears to be superior to RCR in creating excellent ETI conditions and avoiding unacceptable ETI conditions. © 2006 The Authors Journal compilation © 2006 Blackwell Publishing Ltd.