Carboxamide-functionalized cellulose hydrogel as an efficient pH-sensitive antibacterial oral delivery carrier

Mahoutforoush A., Feyzi F., Rasoulzadehzali M., Kazeminava F., Nazari S., Moradi S., ...daha çox

Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol.713, 2025 (SCI-Expanded) identifier

  • Nəşrin Növü: Article / Article
  • Cild: 713
  • Nəşr tarixi: 2025
  • Doi nömrəsi: 10.1016/j.colsurfa.2025.136425
  • jurnalın adı: Colloids and Surfaces A: Physicochemical and Engineering Aspects
  • Jurnalın baxıldığı indekslər: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC
  • Açar sözlər: Cellulose, Oral delivery, Passerini reaction
  • Adres: Bəli

Qısa məlumat

This study leverages the Passerini three-component reaction (P-3CR), a novel and efficient method for crosslinking carboxymethyl cellulose (CMC) via carboxamide frameworks, to develop bioactive antibacterial hydrogels for enhanced oral drug delivery. The synthesized Passerini-crosslinked CMC hydrogels (PC-CMC) demonstrated a remarkable ability to protect encapsulated colistin (CL) from acidic degradation in simulated gastrointestinal tract (GIT) conditions while modulating drug release profiles to enhance bioavailability. Notably, the hydrogels exhibited pH-sensitive release of CL, which is crucial for controlled drug delivery. Antibacterial evaluations revealed that CL-loaded PC-CMC exhibited significant antimicrobial activity against E. coli and S. aureus, with minimum inhibitory concentrations (MIC) ranging from 80 to 160 µg/mL, comparable to existing CMC-based hydrogels in literature. Furthermore, cytotoxicity assessments indicated that PC-CMC displayed favorable cytocompatibility towards human umbilical vein endothelial cells (HUVEC), with cell viability exceeding 80 % over five days. These findings underscore the potential of PC-CMC hydrogels as an efficient pH-sensitive platform for oral antibacterial delivery, addressing critical challenges in antibiotic bioavailability and safety.