Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review

Mushtaq A., Zahoor A. F., Bilal M., Hussain S. M., İRFAN M., Akhtar R., ...daha çox

Molecules, vol.28, no.6, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Nəşrin Növü: Article / Review
  • Cild: 28 Say: 6
  • Nəşr tarixi: 2023
  • Doi nömrəsi: 10.3390/molecules28062722
  • jurnalın adı: Molecules
  • Jurnalın baxıldığı indekslər: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Açar sözlər: alkaloids, enantioselective, flavones, lactones, macrolides, natural products, polyketides, Sharpless asymmetric dihydroxylation
  • Açıq Arxiv Kolleksiyası: Icmal
  • Adres: Bəli

Qısa məlumat

Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand. Sharpless introduced this methodology after considering the importance of enantioselectivity in the total synthesis of medicinally important compounds. Vicinal diols, produced as a result of this reaction, act as intermediates in the synthesis of different naturally occurring compounds. Hence, Sharpless asymmetric dihydroxylation plays an important role in synthetic organic chemistry due to its undeniable contribution to the synthesis of biologically active organic compounds. This review emphasizes the significance of Sharpless asymmetric dihydroxylation in the total synthesis of various natural products, published since 2020.