The Corey-Seebach Reagent in the 21st Century: A Review

Haroon M., Zahoor A. F., Ahmad S., Mansha A., İRFAN M., Mushtaq A., ...daha çox

Molecules, vol.28, no.11, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Nəşrin Növü: Article / Review
  • Cild: 28 Say: 11
  • Nəşr tarixi: 2023
  • Doi nömrəsi: 10.3390/molecules28114367
  • jurnalın adı: Molecules
  • Jurnalın baxıldığı indekslər: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Açar sözlər: alkaloids, Corey-Seebach reagent, natural products
  • Açıq Arxiv Kolleksiyası: Icmal
  • Adres: Bəli

Qısa məlumat

The Corey-Seebach reagent plays an important role in organic synthesis because of its broad synthetic applications. The Corey-Seebach reagent is formed by the reaction of an aldehyde or a ketone with 1,3-propane-dithiol under acidic conditions, followed by deprotonation with n-butyllithium. A large variety of natural products (alkaloids, terpenoids, and polyketides) can be accessed successfully by utilizing this reagent. This review article focuses on the recent contributions (post-2006) of the Corey-Seebach reagent towards the total synthesis of natural products such as alkaloids (lycoplanine A, diterpenoid alkaloids, etc.), terpenoids (bisnorditerpene, totarol, etc.), polyketide (ambruticin J, biakamides, etc.), and heterocycles such as rodocaine and substituted pyridines, as well and their applications towards important organic synthesis.