Carboxamide-functionalized cellulose hydrogel as an efficient pH-sensitive antibacterial oral delivery carrier
Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol.713, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 713
- Publication Date: 2025
- Doi Number: 10.1016/j.colsurfa.2025.136425
- Journal Name: Colloids and Surfaces A: Physicochemical and Engineering Aspects
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC
- Keywords: Cellulose, Oral delivery, Passerini reaction
- Open Archive Collection: Article
- Azerbaijan State University of Economics (UNEC) Affiliated: Yes
Abstract
This study leverages the Passerini three-component reaction (P-3CR), a novel and efficient method for crosslinking carboxymethyl cellulose (CMC) via carboxamide frameworks, to develop bioactive antibacterial hydrogels for enhanced oral drug delivery. The synthesized Passerini-crosslinked CMC hydrogels (PC-CMC) demonstrated a remarkable ability to protect encapsulated colistin (CL) from acidic degradation in simulated gastrointestinal tract (GIT) conditions while modulating drug release profiles to enhance bioavailability. Notably, the hydrogels exhibited pH-sensitive release of CL, which is crucial for controlled drug delivery. Antibacterial evaluations revealed that CL-loaded PC-CMC exhibited significant antimicrobial activity against E. coli and S. aureus, with minimum inhibitory concentrations (MIC) ranging from 80 to 160 µg/mL, comparable to existing CMC-based hydrogels in literature. Furthermore, cytotoxicity assessments indicated that PC-CMC displayed favorable cytocompatibility towards human umbilical vein endothelial cells (HUVEC), with cell viability exceeding 80 % over five days. These findings underscore the potential of PC-CMC hydrogels as an efficient pH-sensitive platform for oral antibacterial delivery, addressing critical challenges in antibiotic bioavailability and safety.