Synthesis, crystal structure and Hirshfeld surface analysis of 5-oxo-N-phenyl-3-(thiophen-2-yl)- 2,3,4,5-tetrahydro-[1,10-biphenyl]-4-carboxamide
Acta Crystallographica Section E: Crystallographic Communications, vol.81, no.Pt 2, pp.177-182, 2025 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 81 Issue: Pt 2
- Publication Date: 2025
- Doi Number: 10.1107/s205698902500057x
- Journal Name: Acta Crystallographica Section E: Crystallographic Communications
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
- Page Numbers: pp.177-182
- Keywords: biphenyl-4- carboxamide, carboxamide, crystal structure, hydrogen bond, thiophene disorder
- Open Archive Collection: Article, Digital Heritage Collection
- Azerbaijan State University of Economics (UNEC) Affiliated: Yes
Abstract
The asymmetric unit of the title compound, C23H19NO2S, contains two molecules that differ in the conformation of the two carboxamide moieties. In the crystal, intermolecular N - H⋯O hydrogen bonds link the molecules into chains propagating parallel to the c-axis direction. Between the molecules, weak C - H⋯π(ring) interactions are present, whereas π-π interactions are not observed. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions to the crystal packing are from H⋯H (47.6%), H⋯C/C⋯H (33.4%) and H⋯O/O⋯H (11.6%) interactions. Orientational disorder is observed for both thiophene rings.