Direct C-H difluoromethyl(thiol/selenol)ation of terminal alkynes: A review

Khadijeh, Didehban; Niyazova, AYTƏN; Mirzəyev, GƏRAY; Allahverdiyeva, İLHAMƏ

Direct C-H difluoromethyl(thiol/selenol)ation of terminal alkynes: A review

Khadijeh D., Niyazova A., Mirzəyev G., Allahverdiyeva I.

Chemical Review and Letters, vol.8, pp.68-76, 2025 (Scopus)

Publication Type: Article / Article
Volume: 8
Publication Date: 2025
Journal Name: Chemical Review and Letters
Journal Indexes: Scopus
Page Numbers: pp.68-76
Open Archive Collection: Article, Digital Heritage Collection
Azerbaijan State University of Economics (UNEC) Affiliated: Yes

Abstract

The aim of the present review is to summarize the recent advances in the direct CH difluoromethyl(chalcogen)ation of terminal alkynes. Hopefully, it can provide practical guidance for the readers who are interested in fluoroalkylation reactions. For simplicity and clarity, the review is divided into three sections: (i) difluoromethylation reactions; (ii) difluoromethylthiolation reactions; and (iii) difluoromethylselenolation reactions. © 2025, Iranian Chemical Science and Technologies Association. All rights reserved.