Oral delivery of proteins and peptides by mucoadhesive nanoparticles

Sharifi S., Samani A. A., Ahmədian E., Eftekhari A., Derakhshankhah H., Jafari S., ...More

Biointerface Research in Applied Chemistry, vol.9, no.2, pp.3849-3852, 2019 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.33263/briac92.849852
  • Journal Name: Biointerface Research in Applied Chemistry
  • Journal Indexes: Scopus
  • Page Numbers: pp.3849-3852
  • Keywords: Mucoadhesive nanoparticles, Nanotechnology, Oral delivery
  • Open Archive Collection: Article
  • Azerbaijan State University of Economics (UNEC) Affiliated: Yes

Abstract

It seems that an ever growing tendency is necessary for the development of a strategy that can not only protect the peptides and proteins from degradation by the enzymes but also can improve their absorption without affecting biological activity. Delivery of peptides and proteins into the oral cavity remains an interesting approach, however for its availability some distinctive problems should be addressed. A wide variety of carriers have been investigated for delivery of peptides and proteins for the protection of their formulation and structure against the enzymatic environment of the gastrointestinal tract.