Role of renin-angiotensin system in liver diseases: an outline on the potential therapeutic points of intervention

Ahmədian E., Pennefather P. S., Eftekhari A., Heidari R., Eghbal M. A.

Expert Review of Gastroenterology and Hepatology, vol.10, no.11, pp.1279-1288, 2016 (SCI-Expanded, Scopus) identifier identifier

  • Nəşrin Növü: Article / Review
  • Cild: 10 Say: 11
  • Nəşr tarixi: 2016
  • Doi nömrəsi: 10.1080/17474124.2016.1207523
  • jurnalın adı: Expert Review of Gastroenterology and Hepatology
  • Jurnalın baxıldığı indekslər: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Səhifə sayı: pp.1279-1288
  • Açar sözlər: angiotensin converting enzyme inhibitor, angiotensin II, angiotensin receptor blocker, anti-oxidant, liver disease, NADPH oxidase, oxidative stress, Renin–angiotensin system
  • Açıq Arxiv Kolleksiyası: Icmal
  • Adres: Bəli

Qısa məlumat

Introduction: The current review aimed to outline the functions of the renin angiotensin system (RAS) in the context of the oxidative stress-associated liver disease. Areas covered: Angiotensin II (Ang II) as the major effector peptide of the RAS is a pro-oxidant and fibrogenic cytokine. Mechanistically, NADPH oxidase (NOX) is a multicomponent enzyme complex that is able to generate reactive oxygen species (ROS) as a downstream signaling pathway of Ang II which is expressed in liver. Ang II has a detrimental role in the pathogenesis of chronic liver disease through possessing pro-oxidant, fibrogenic, and pro-inflammatory impact in the liver. The alternative axis (ACE2/Ang(1-7)/mas) of the RAS serves as an anti-inflammatory, antioxidant and anti-fibrotic component of the RAS. Expert commentary: In summary, the use of alternative axis inhibitors accompanying with ACE2/ Ang(1-7)/mas axis activation is a promising new strategy serving as a novel therapeutic option to prevent and treat chronic liver diseases.