An update on calcium carbonate nanoparticles as cancer drug/gene delivery system

Maleki Dizaj S., Sharifi S., Ahmədian E., Eftekhari A., Adibkia K., Lotfipour F.

Expert Opinion on Drug Delivery, vol.16, no.4, pp.331-345, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 16 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1080/17425247.2019.1587408
  • Journal Name: Expert Opinion on Drug Delivery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.331-345
  • Keywords: CaCO 3 nanoparticles, cancer, drug delivery, gene delivery
  • Open Archive Collection: Review
  • Azerbaijan State University of Economics (UNEC) Affiliated: Yes

Abstract

Introduction: In recent years, the applications of calcium carbonate (CaCO 3 ) nanoparticles (NPs) have gained extensive interest as targeted drug/gene delivery systems to cancerous tissues and cells due to their accessibility, low cost, safety, biocompatibility, pH-sensitivity, and slow biodegradability. Areas covered: Drug-loaded CaCO 3 NPs (CCNPs) have been reviewed. An updated search on the current state of CCNPs as cancer drug/gene delivery systems with a focus on their special properties including pH-sensitivity, biodegradability, and sustained release performance has been also assessed. Expert opinion: Based on the reviewed literature, CCNPs, because of their superior features, will have a great aiding role in safe and efficient cancer treatment in the near future.