Recent advances in direct 1,2-bis-trifluoro-methylation,-methoxylation,-methylthiolation, and-methylselenylation of unsaturated hydrocarbons
JOURNAL OF FLUORINE CHEMISTRY, vol.285, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 285
- Publication Date: 2025
- Doi Number: 10.1016/j.jfluchem.2025.110454
- Journal Name: JOURNAL OF FLUORINE CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica
- Azerbaijan State University of Economics (UNEC) Affiliated: No
Abstract
Owing to its high efficiency, substrate versatility, operational simplicity, and product structure diversity, difunctionalization is a topic of current interest. In this context, some attention has been recently paid to the direct 1,2-bis-trifluorometh(ox)yl(thiol/selenyl)ation of abundant and easily accessible unsaturated hydrocarbons for the single-step construction of biologically important 1,2-bis(trifluoro-methyl/methoxyl/thiol/selenyl) ated compounds. In this Mini-Review, we summarize the recent progress and advances in this attractive field with emphasis on the mechanistic aspect of these reactions.