Experımental Study: The Effect Of 20% Intralıpıd Emulsıon Therapy In Cerebral Ischemıc Reperfusıon

Şimşek C., Tav Şimşek D., ÖZÜÇELİK D. N., Sümer E., Hacıhasanoğlu E., Sarıkaya S.

Brain Injury, vol.38, no.6, pp.489-498, 2024 (SCI-Expanded) identifier identifier

  • Nəşrin Növü: Article / Article
  • Cild: 38 Say: 6
  • Nəşr tarixi: 2024
  • Doi nömrəsi: 10.1080/02699052.2024.2318596
  • jurnalın adı: Brain Injury
  • Jurnalın baxıldığı indekslər: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo
  • Səhifə sayı: pp.489-498
  • Açar sözlər: cerebral histopathological findings, cerebral reperfusion injury, Experimental study, Intralipid Emulsion therapy, stroke
  • Adres: Yox

Qısa məlumat

Background: This experimental study was conducted to investigate the effect of 20% Intralipid Emulsion (ILE) treatment on Cerebral Ischemia Reperfusion Injury (CIRI) after reperfusion in acute ischemic stroke. Methods: In this experimental study, seven rats without any intervention (control group), seven rats (sham group) for which CIRI was created after the common carotid artery was ligated for 2 hours, and seven rats who were treated with 20% ILE after CIRI (CIRI + ILE group) were sacrificed after 24 hours, and histopathological findings were investigated. Results: In rats that were not treated after CIRI, 52.7% had level-1, 32.7% had level-2. and 14.5% had level-3. histopathological findings. While 72.2% of the rats treated with ILE had level-1 and 27.8% had level-2 findings, no level-3 histopathological findings were detected in any of the rats. While no signs of coagulative necrosis, spongiosis of surrounding tissue and polymorphonuclear leukocytes were observed histopathological in any of the rats given ILE, there was no macrophages finding in 85.6% of the rats. ILE treatment also reduced the histopathological findings of eosinophilic neurons, astrogliosis, neovascularization, vascular thrombosis and mononuclear inflammatory cells. Conclusion: This study showed that 20% ILE treatment reduces the histopathological damage seen in cerebral ischemia and CIRI.