Trizma: Efficient catalyst and reactant in knoevenagel condensation reaction under conventional heat and microwave irradiation conditions

Mohamed S. K., Abdelhamid A. A., Maharramov A., Xəlilov Ə., Gurbanov A. V., Allahverdiev M.

Journal of Chemical and Pharmaceutical Research, vol.4, no.3, pp.1787-1793, 2012 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2012
  • Journal Name: Journal of Chemical and Pharmaceutical Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.1787-1793
  • Keywords: Carbonyl compounds, Knoevenagel condensation, Microwave irradiation, Trizma
  • Azerbaijan State University of Economics (UNEC) Affiliated: Yes

Abstract

Knoevenagel condensation of several aromatic aldehydes 1 with different active methylene compounds 2 under conventional heat condition was efficiently mediated by TRIZMA as a benign catalyst to afford the corresponding arylidenes 3 in excellent yield. In the same reaction the yield has dramatically reduced when microwave irradiation was employed under nitrogen while when the irradiation has carried out in presence of oxygen air TRIZMA showed an extraordinary reactivity and N1-(1,1-diethylpropyl)-N2-(1-ethyl-1-hydroxymethylpropyl) ethanediamide 4 was obtained instead.